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M9490463.TXT
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1994-09-19
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Document 0463
DOCN M9490463
TI Successful treatment of a patient with seropositive human
immunodeficiency virus with high risk Burkitt's leukemia.
DT 9411
AU Greenberg AL; Droller DG; Department of Medicine, University of Miami
School of Medicine,; Florida.
SO Cancer. 1994 Aug 15;74(4):1261-4. Unique Identifier : AIDSLINE
MED/94332776
AB A 24-year-old male patient seropositive for the human immunodeficiency
virus with Burkitt's Leukemia was treated successfully with aggressive
systemic chemotherapy and central nervous system prophylaxis. He
presented with a leukocyte count of 68,900/microliter with 33% L3
lymphoblasts, massive hepatosplenomegaly, generalized lymphadenopathy, a
lactic dehydrogenase level of 9105 IU/l, creatinine level of 5.8 mg/dl,
and a uric acid level of 43.5 mg/dl. Hemodialysis, intrathecal
methotrexate, hydrocortisone and cytosine arabinoside, and fractionated
doses of cyclophosphamide followed by vincristine and doxorubicin were
promptly instituted. He received eight subsequent courses of
chemotherapy consisting of either methotrexate with leucovorin rescue
and high dose, continuous infusion cytosine arabinoside or
cyclophosphamide, vincristine, and methotrexate with leucovorin. There
was marked hematologic toxicity resulting from this treatment. However,
the patient was alive and in complete remission more than 6 years from
diagnosis. This paper demonstrated that it is possible to successfully
treat a patient who is HIV-1 antibody positive with poor prognosis
Burkitt's Leukemia. Further studies need to be undertaken to define the
least toxic, most effective therapy for this disease.
DE Adult Antineoplastic Agents, Combined/ADMINISTRATION & DOSAGE/
*THERAPEUTIC USE Case Report Combined Modality Therapy
Cyclophosphamide/ADMINISTRATION & DOSAGE Cytarabine/ADMINISTRATION &
DOSAGE Doxorubicin/ADMINISTRATION & DOSAGE Hemodialysis Human
Hydrocortisone/ADMINISTRATION & DOSAGE HIV
Seropositivity/*COMPLICATIONS Injections, Intravenous Injections,
Spinal Leukemia, B-Cell, Acute/*COMPLICATIONS/*DRUG THERAPY Male
Methotrexate/ADMINISTRATION & DOSAGE Remission Induction
Vincristine/ADMINISTRATION & DOSAGE JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).